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The underlying cause of the Bowditch effect is an increase in the calcium concentration in the sarcoplasmic reticulum of cardiac muscle cells, and its increased release into sarcoplasm. [ 3 ] One of the explanations for an increase in the intracellular calcium concentration is the inability of the Na + /K + -ATPase to keep up with influx of ...
Cardiac muscle (also called heart muscle or myocardium) is one of three types of vertebrate muscle tissues, the others being skeletal muscle and smooth muscle. It is an involuntary, striated muscle that constitutes the main tissue of the wall of the heart .
[11] [12] Further, this adrenaline surge triggers the arteries to tighten, thereby raising blood pressure and placing more stress on the heart, and may lead to spasm of the coronary arteries that supply blood to the heart muscle. [10] This impairs the arteries from delivering adequate blood flow and oxygen to the heart muscle. [10]
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Heart muscle is subject to two kinds of stress: physiologic stress, i.e. exercise; and pathologic stress, i.e. disease related. Likewise, the heart has two potential responses to either stress: cardiac hypertrophy, which is a normal, physiologic, adaptive growth; or cardiac remodeling, which is an abnormal, pathologic, maladaptive growth. Upon ...
These are known as transverse-tubules (t-tubules); which are also found in skeletal muscle cells and allow for the action potential to travel into the centre of the cell. [7] Special proteins called L-type calcium channels (also known as dihydropyridine receptors (DHPR)) are located on the t-tubule membrane, and are activated by the action ...
In patients with stable coronary heart disease (CHD) up to 70% [1] Mental stress-induced myocardial ischemia (MSIMI) is a medical condition in which acute psychological stress can trigger a transient myocardial ischemia , which is a state of reduced blood flow to the heart muscle , often without the presence of significant coronary artery ...
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