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The first synthesis of atorvastatin at Parke-Davis that occurred during drug discovery was racemic followed by chiral chromatographic separation of the enantiomers. An early enantioselective route to atorvastatin made use of an ester chiral auxiliary to set the stereochemistry of the first of the two alcohol functional groups via a ...
Smith v. United States, 508 U.S. 223 (1993), is a United States Supreme Court case that held that the exchange of a gun for drugs constituted "use" of the firearm for purposes of a federal statute imposing penalties for "use" of a firearm "during and in relation to" a drug trafficking crime.
The exact mechanism responsible for the possible increased risk of diabetes mellitus associated with statin use is unclear. [105] However, recent findings have indicated the inhibition of HMGCoAR as a key mechanism. [109] Statins are thought to decrease cells' uptake of glucose from the bloodstream in response to the hormone insulin. [105]
The Supreme Court handed down a landmark decision Monday granting Donald Trump partial immunity from special counsel Jack Smith’s election subversion case, handing the former president a ...
Decisions that do not note a Justice delivering the Court's opinion are per curiam. Multiple concurrences and dissents within a case are numbered, with joining votes numbered accordingly. Justices frequently join multiple opinions in a single case; each vote is subdivided accordingly.
The Supreme Court, drunk on arrogated power, cut loose from rudimentary ethics, has been eaten alive by it. But the court is just one plot of a vast terrain that Trump has conquered — not with ...
John Sauer, who argued the immunity dispute on Trump’s behalf before the Supreme Court, has been selected by Trump to be US solicitor general, the federal government’s top lawyer before the ...
Smith v. United States , 568 U.S. 106 (2013), was a case decided by the Supreme Court of the United States of America . [ 1 ] The case was argued on November 6, 2012, and decided on January 9, 2013.