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In most of Europe, glucosamine is approved as a medical drug and is sold in the form of glucosamine sulfate. [33] In this case, evidence of safety and efficacy is required for the medical use of glucosamine and several guidelines have recommended its use as an effective and safe therapy for osteoarthritis.
A significant amount of research has been performed on glycosaminoglycans, especially glucosamine and chondroitin, for the treatment of arthritis.These compounds are commonly marketed as nutritional supplements and numerous 'soft therapeutic claims' are made about their health benefits - especially in aging populations. [1]
Due to the potential complications that can occur as a result of diarrhea in older adults, diacerein is no longer recommended in patients aged 65 years and above. It is also advised that patients start treatment on half the normal dose (i.e. 50 mg daily instead of 100 mg daily), and should stop taking diacerein if diarrhea occurs.
The bioavailability of chondroitin sulfate ranges from 15% to 24% of the orally administered dose. More particularly, on the articular tissue, Ronca et al. [ 19 ] reported that chondroitin sulfate is not rapidly absorbed in the gastro-intestinal tract and a high content of labeled chondroitin sulfate is found in the synovial fluid and cartilage.
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On its own, Glucosamine Sulfate is commonly prescribed to treat “inflammation, breakdown, and eventual loss of cartilage (osteoarthritis).” [7] However, the relief is short-term. A double-blind study has recently proven that significant increase in effectivity when Glucosamine Sulfate is used in tandem with Celadrin.
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