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Methemoglobinemia, or methaemoglobinaemia, is a condition of elevated methemoglobin in the blood. [2] Symptoms may include headache, dizziness, shortness of breath, nausea, poor muscle coordination, and blue-colored skin (cyanosis). [2] Complications may include seizures and heart arrhythmias. [3][4]
Methemoglobin. The structure of cytochrome b5 reductase, the enzyme that converts methemoglobin to hemoglobin. [1] Methemoglobin (British: methaemoglobin, shortened MetHb) (pronounced "met-hemoglobin") is a hemoglobin in the form of metalloprotein, in which the iron in the heme group is in the Fe 3+ (ferric) state, not the Fe 2+ (ferrous) of ...
Sulfhemoglobinemia. Sulfhemoglobinemia is a rare condition in which there is excess sulfhemoglobin (SulfHb) in the blood. The pigment is a greenish derivative of hemoglobin which cannot be converted back to normal, functional hemoglobin. It causes cyanosis even at low blood levels. It is a rare blood condition in which the β-pyrrole ring of ...
Methemoglobin is also formed in small quantities when the dissociation of oxyhemoglobin results in the formation of methemoglobin and superoxide, O 2 −, instead of the usual products. Superoxide is a free radical and causes biochemical damage, but is neutralised by the action of the enzyme superoxide dismutase.
Cytochrome-b5 reductase is a NADH -dependent enzyme that converts ferricytochrome from a Fe3+ form to a Fe2+ form. [1] It contains FAD and catalyzes the reaction: NADH + H + + 2 ferricytochrome b5 = NAD + + 2 ferrocytochrome b5. In its b5-reducing capacity, this enzyme is involved in desaturation and elongation of fatty acids, cholesterol ...
Specialty. Hematology. Hemoglobinopathy is the medical term for a group of inherited blood disorders involving the hemoglobin, the protein of red blood cells. [1] They are single-gene disorders and, in most cases, they are inherited as autosomal co-dominant traits. [2]
The disorder can cause heart abnormalities and seizures if the amount of methemoglobin in the blood exceeds 20 percent, but at levels between 10 and 20 percent it can cause blue skin without other symptoms. Most of the Fugates lived long and healthy lives. The "bluest" of the blue Fugates, Luna Stacy, had 13 children and lived to age 84. [6]
Hemoglobinemia (or haemoglobinaemia) is a medical condition in which there is an excess of hemoglobin in the blood plasma. This is an effect of intravascular hemolysis, in which hemoglobin separates from red blood cells, a form of anemia. Hemoglobinemia can be caused by intrinsic or extrinsic factors. When hemoglobinemia is internally caused ...