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Ledipasvir is a drug for the treatment of hepatitis C that was developed by Gilead Sciences. [1] After completing Phase III clinical trials, on February 10, 2014, Gilead filed for U.S. approval of a ledipasvir/sofosbuvir fixed-dose combination tablet for genotype 1 hepatitis C. [2] [3] The ledipasvir/sofosbuvir combination is a direct-acting antiviral agent that interferes with HCV replication ...
Sofosbuvir/velpatasvir, sold under the brand name Epclusa among others, is a fixed-dose combination medication for the treatment of hepatitis C in adults. [2] [5] [6] [7] It combines sofosbuvir and velpatasvir. [2] [5] [6] It is more than 90% effective for hepatitis C genotypes one through six. [2]
The initial recommended treatment depends on the type of hepatitis C virus, if the person has received previous hepatitis C treatment, and whether the person has cirrhosis. [88] Direct-acting antivirals are the preferred treatment and have been validated by testing for virus particles in patients' blood.
In all cases, after just 12 weeks of treatment, 95 percent of people diagnosed with hepatitis C are cured. How to Prevent Hepatitis C Cured of hepatitis C, however, doesn’t mean immune.
Hepatitis C treatment guidelines also vary based on whether you have cirrhosis (scarring of the liver) and how severe it is. Related: 15 Celebrities With Hepatitis C, from Natasha Lyonne to David ...
Sofosbuvir is also used with other medications and longer treatment durations, depending on specific circumstances, genotype and cost-effectiveness–based perspective. For example, for the treatment of genotypes 1, 4, 5, and 6 hepatitis C infections, sofosbuvir can be used in combination with the viral NS5A inhibitor ledipasvir. [16]
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