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Testosterone is the primary male sex hormone and androgen in males. [3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.
5α-Dihydrotestosterone (DHT) was 2.4 times more potent than testosterone at maintaining normal prostate weight and duct lumen mass (this is a measure of epithelial cell function stimulation). Whereas DHT was equally potent as testosterone at preventing prostate cell death after castration. [24]
Chemical Class Abbreviation Tissue Cells Receptor Target Tissue Effect Testosterone: androgen: testes, ovary: Leydig cells: AR: libido, Anabolic: growth of muscle mass and strength, increased bone density, growth and strength, Virilizing: maturation of sex organs, formation of scrotum, deepening of voice, growth of beard and axillary hair.
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“About 10 to 20 percent of men will have low testosterone in their life, and they have at least 11 FDA-approved products,” Casperson says. “One hundred percent of women will have low ...
By the 10th-12th week, the genitalia are distinctly male or female being and derived from their homologous structures. At 16 weeks post-conception, the genitalia are formed and distinct. [8] [9] The masculinization of the embryonic reproductive structures occurs as a result of testosterone secreted by the embryonic testes.
The elimination of testosterone in adulthood has been shown to reduce sexual motivation in both male humans and male primates. [1] Male humans who had their testicular function suppressed with a GnRH antagonist displayed decreases in sexual desire and masturbation two weeks following the procedure. [2]
Circulating DHT levels in eugonadal men are about 7- to 10-fold lower than those of testosterone, and plasma levels of testosterone and DHT are highly correlated (correlation coefficient of 0.7). [5] [7] In contrast to the circulation however, levels of DHT in the prostate gland are approximately 5- to 10-fold higher than those of testosterone. [7]
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