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Levofloxacin and other fluoroquinolones have also been widely used for the treatment of uncomplicated community-acquired respiratory and urinary tract infections, indications for which major medical societies generally recommend the use of older, narrower spectrum drugs to avoid fluoroquinolone resistance development.
Fluoroquinolones are often used for genitourinary tract infections [5] and are widely used in the treatment of hospital-acquired infections associated with urinary catheters. In community-acquired infections , they are recommended only when risk factors for multidrug resistance are present or after other antibiotic regimens have failed.
Urinary tract infection in pediatric patients is a significant clinical issue, affecting approximately 7% of fevered infants and children. [43] If left untreated, the infection can ascend from the bladder to the kidneys, resulting in acute pyelonephritis, which leads to hypertension , kidney scarring , and end-stage kidney disease .
Quinolones/Fluoroquinolones Ciprofloxacin: Cipro, Ciproxin, Ciprobay: Urinary tract infections, bacterial prostatitis, community-acquired pneumonia, bacterial diarrhea, mycoplasmal infections, gonorrhea: Nausea (rare), irreversible damage to central nervous system (uncommon), tendinosis (rare)
Levofloxacin, which is marketed under the brand name Levaquin in the U.S. and Tavanic in the EU, is often prescribed for pneumonia, urinary tract infections and infections of the abdomen.
Norfloxacin, sold under the brand name Noroxin among others, is an antibiotic [1] [2] that belongs to the class of fluoroquinolone antibiotics.It is used to treat urinary tract infections, gynecological infections, inflammation of the prostate gland, gonorrhea and bladder infection.
Ofloxacin is a quinolone antibiotic useful for the treatment of a number of bacterial infections. [1] When taken by mouth or injection into a vein, these include pneumonia, cellulitis, urinary tract infections, prostatitis, plague, and certain types of infectious diarrhea.
Their use in surgical procedures is to help prevent infection of incisions. They have an important role in dental antibiotic prophylaxis where their use may prevent bacteremia and consequent infective endocarditis. Antibiotics are also used to prevent infection in cases of neutropenia particularly cancer-related. [37] [38]
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