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A diagnosis of vitamin B 12 deficiency is determined by blood levels lower than 200 or 250 picograms per ml (148 or 185 picomoles per liter). Measurement of blood methylmalonic acid (MMA), a vitamin B 12 -associated metabolite, is a commonly used biomarker . [ 2 ]
This is a shortened version of the third chapter of the ICD-9: Endocrine, Nutritional and Metabolic Diseases, and Immunity Disorders. It covers ICD codes 240 to 279 . The full chapter can be found on pages 145 to 165 of Volume 1, which contains all (sub)categories of the ICD-9.
ICD-9 chapters; Chapter Block Title I 001–139: Infectious and Parasitic Diseases II 140–239: Neoplasms III 240–279: Endocrine, Nutritional and Metabolic Diseases, and Immunity Disorders IV 280–289: Diseases of the Blood and Blood-forming Organs V 290–319: Mental Disorders VI 320–389: Diseases of the Nervous System and Sense Organs ...
Vitamin B 12 deficiency has been observed in between 40% and 80% of the vegetarian population who do not also take a vitamin B 12 supplement or consume vitamin-fortified food. [36] In Hong Kong and India, vitamin B 12 deficiency has been found in roughly 80% of the vegan population.
The Schilling test distinguished PA from other forms of B 12 deficiency, [50] specifically, from Imerslund–Gräsbeck syndrome, a B 12-deficiency caused by mutations in CUBN that codes for cubilin the cobalamin receptor. [1] Vitamin B12 deficiency is also prevalent in patients having Crohn's disease (CD) so it should be differentiated. [62]
Methylmalonyl-CoA requires vitamin B 12 to form succinyl-CoA. When the amount of B 12 is insufficient for the conversion of cofactor methylmalonyl-CoA into succinyl-CoA, the buildup of unused methylmalonyl-CoA eventually leads to methylmalonic acidemia. This diagnosis is often used as an indicator of vitamin B 12 deficiency in serum. [38]
This is a shortened version of the sixteenth chapter of the ICD-9: Symptoms, Signs and Ill-defined Conditions. It covers ICD codes 780 to 799. The full chapter can be found on pages 455 to 471 of Volume 1, which contains all (sub)categories of the ICD-9. Volume 2 is an alphabetical index of Volume 1.
Folate deficiency can be secondary to vitamin B 12 deficiency or a defect in homocysteine methyl transferase that leads to a "folate trap" in which is an inactive metabolite that cannot be recovered. [1] Diagnosis is typically confirmed by blood tests, including a complete blood count, and serum folate levels. [1]