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Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor/metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids. [1]
In the first step in the steroidogenic pathway, cholesterol is converted into pregnenolone, which serves as the precursor to the progestogens progesterone and 17α-hydroxyprogesterone. These progestogens, along with another steroid, 17α-hydroxypregnenolone , are the precursors of all other endogenous steroids, including the androgens ...
Pregnenolone, sold under the brand name Enelone among others, is a medication and supplement as well as a naturally occurring and endogenous steroid. [3] [1] [4] [5] [6] It is described as a neurosteroid and anti-inflammatory drug and was used in the treatment of rheumatoid arthritis and soft-tissue rheumatism in the 1950s and is no longer prescribed today, but remains available as a supplement.
A steroid hormone is a steroid that acts as a hormone.Steroid hormones can be grouped into two classes: corticosteroids (typically made in the adrenal cortex, hence cortico-) and sex steroids (typically made in the gonads or placenta).
1583 13070 Ensembl ENSG00000140459 ENSG00000288362 ENSMUSG00000032323 UniProt P05108 Q9QZ82 RefSeq (mRNA) NM_001099773 NM_000781 NM_019779 NM_001346787 RefSeq (protein) NP_000772 NP_001093243 NP_001333716 NP_062753 Location (UCSC) Chr 15: 74.34 – 74.37 Mb Chr 9: 57.91 – 57.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cholesterol side-chain cleavage enzyme is commonly ...
Pregnanolone, also known as 3α,5β-tetrahydroprogesterone (3α,5β-THP) or as 5β-pregnan-3α-ol-20-one, is a naturally occurring pregnane steroid and a derivative of progesterone.
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Corticosterone has only weak glucocorticoid and mineralocorticoid potencies in humans and is important mainly as an intermediate in the steroidogenic pathway from pregnenolone to aldosterone. Corticosterone is converted to aldosterone by aldosterone synthase, found only in the mitochondria of glomerulosa cells.
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