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Radioactive iodine (iodine-131) alone can potentially worsen thyrotoxicosis in the first few days after treatment. One side effect of treatment is an initial period of a few days of increased hyperthyroid symptoms. This occurs because when the radioactive iodine destroys the thyroid cells, they can release thyroid hormone into the blood stream.
The patient swallows a radioisotope of iodine in the form of capsule or fluid, and the absorption (uptake) of this radiotracer by the thyroid is studied after 4–6 hours and after 24 hours with the aid of a scintillation counter. The dose is typically 0.15–0.37 MBq (4–10 μCi) of 131 I iodide, or 3.7–7.4 MBq (100–200 μCi) of 123 I ...
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The uptake test involves administering a dose of radioactive iodine (radioiodine), traditionally iodine-131 (131 I), and more recently iodine-123 (123 I). Iodine-123 may be the preferred radionuclide in some clinics due to its more favorable radiation dosimetry (i.e. less radiation dose to the person per unit administered radioactivity) and a ...
Radioactive Iodine Therapy. This treatment involves taking radioactive iodine by mouth in order to destroy the overactive cells, per Lowe. Beta-Blockers.
Unlike the Wolff–Chaikoff effect, the Plummer effect does not prevent the thyroid from taking up radioactive iodine, e.g. in the case of nuclear emergencies.Therefore, "plummering" with high-dose iodine is only effective in a short time window after the release of radionuclides. [9]
In some ways the Jod-Basedow phenomenon is the opposite of two physiological compensation mechanisms, the Plummer effect and the Wolff–Chaikoff effect, which in normal persons and in persons with thyroid disease, suppress the thyroid hormone after ingestion of large quantities of iodine or iodide. However, unlike the Plummer and Wolff ...
The beta radiation released damages both normal thyroid tissue and any thyroid cancer that behaves like normal thyroid in taking up iodine, so providing the therapeutic effect, whilst most of the gamma radiation escapes the patient's body. [7] Most of the iodine not taken up by thyroid tissue is excreted through the kidneys into the urine.