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Merkel cells, also known as Merkel–Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for light touch sensation and found in the skin of vertebrates. They are abundant in highly sensitive skin like that of the fingertips in humans , and make synaptic contacts with somatosensory afferent nerve fibers .
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about three people per million members of the population. [1] It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. [2]
Merkel cell carcinoma (also known as Merkel cell skin cancer) is a rare type of cancer where malignant cells form in the skin, according to the National Cancer Institute (NCI).
Merkel cell polyomavirus (MCV or MCPyV) was first described in January 2008 in Pittsburgh, Pennsylvania. [1] It was the first example of a human viral pathogen discovered using unbiased metagenomic next-generation sequencing with a technique called digital transcriptome subtraction. [2]
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The Merkel cell expresses the PIEZO2 mechanosensitive ion channels; mechanical activation of the channel causes depolarisation of the Merkel cell and consequent release of [1] serotonin into a synapse with the associated nerve ending, to also depolarise the later. [3] The nerve ending meanwhile expresses an unknown mechanosensitive channel. [1]
Buffett, 76, had been fighting Merkel Cell Skin Cancer for four years. He continued to perform during treatment, playing his last show, Jimmy Buffett's cause of death has been revealed. An ...