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This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification. Chemical/generic names are listed first, with brand names in parentheses.
Depressants, colloquially known as "downers" or central nervous system (CNS) depressants, are drugs that lower neurotransmission levels, decrease the electrical activity of brain cells, or reduce arousal or stimulation in various areas of the brain. [1]
Tofranil – a tricyclic antidepressant used to treat depression, anxiety, agitation, panic disorder and bedwetting; Topamax – an anticonvulsant used to treat epilepsy and migraine headaches; Trileptal (oxcarbazepine) – an anticonvulsant used as a mood stabilizer
The α 2 receptors include presynaptic autoreceptors which limit the neurophysiological activity of noradrenergic neurons in the central nervous system. Formation of norepinephrine is reduced by autoreceptors through the rate-limiting enzyme tyrosine hydroxylase , an effect mediated by decreased cyclic AMP -mediated phosphorylation -activation ...
(4) See list of investigational antidepressants for an extensive list of modern investigational antidepressants (including discontinued agents). The earliest and most widely known scientific theory of antidepressant action is the monoamine hypothesis , which can be traced back to the 1950s and 1960s.
Antidepressants are recommended as an alternative or additional first step to self-help programs in the treatment of bulimia nervosa. [36] SSRIs (fluoxetine in particular) are preferred over other anti-depressants due to their acceptability, tolerability, and superior reduction of symptoms in short-term trials.
This is a list of investigational antidepressants, or drugs that are currently under development for clinical use in the treatment of depression but are not yet approved. Specific indications include major depressive disorder , treatment-resistant depression , dysthymia , bipolar depression , and postpartum depression , among others.
Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1] They act by antagonizing the α 2 -adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C , [ 1 ] but also 5-HT 3 , [ 1 ] 5-HT 6 , and/or 5-HT 7 in some cases.