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The onset of a myotoxic episode can occur within a few hours to a few days after local anaesthetic (LA) administration. A greater concentration and longer exposure to LA have been found to have a positive correlation with myotoxic effects. It can take human muscles from 4 days to a year to recover from a myotoxic insult.
Also if the needle is placed too medially the medial pterygoid muscle can be injected, resulting in trismus. The sphenomandibular ligament may act as a barrier to the agent if the injection is given too shallow and the lingual nerve is only anesthetized. [3] This injection can rarely cause needle tract infections of the pterygomandibular space.
Paresthesias are usually painless and can occur anywhere on the body, but most commonly occur in the arms and legs. [1] The most familiar kind of paresthesia is the sensation known as "pins and needles" after having a limb "fall asleep". A less well-known and uncommon paresthesia is formication, the sensation of insects crawling on the skin.
Postoperative cognitive dysfunction (POCD) is a decline in cognitive function (especially in memory and executive functions) that may last from 1–12 months after surgery, or longer. [1] In some cases, this disorder may persist for several years after major surgery. [ 2 ]
Hypoesthesia or numbness is a common side effect of various medical conditions that manifests as a reduced sense of touch or sensation, or a partial loss of sensitivity to sensory stimuli. In everyday speech this is generally referred to as numbness.
Emergence delirium has been associated long-term changes neurocognitive dysfunction after cardiac surgery. [ 8 ] A cohort study which included 560 adults aged 70 years and older for a period of 6 years revealed that delirium represents the most common post-operative complication and is associated with long-term cognitive decline and increased ...
Peripheral neuropathy may first be considered when an individual reports symptoms of numbness, tingling, and pain in feet. After ruling out a lesion in the central nervous system as a cause, a diagnosis may be made on the basis of symptoms, laboratory and additional testing, clinical history, and a detailed examination.
These symptoms generally begin with the or third cycle of treatment and can last long after treatment completion. Indeed, the “coasting” phenomenon mentioned in the Symptoms section is a direct effect of platinum agents. Of the platinum compounds, research has shown cisplatin to be the most frequently involved in peripheral neuropathy. [3]