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In organic chemistry, the propargyl group is a functional group of 2-propynyl with the structure CH≡C−CH 2 −. It is an alkyl group derived from propyne ( HC≡C−CH 3 ). The term propargylic refers to a saturated position ( sp 3 -hybridized ) on a molecular framework next to an alkynyl group.
Propargyl alcohol, or 2-propyn-1-ol, is an organic compound with the formula C 3 H 4 O. It is the simplest stable alcohol containing an alkyne functional group. [ 3 ] Propargyl alcohol is a colorless viscous liquid that is miscible with water and most polar organic solvents.
Propargyl bromide is a lachrymator and an alkylating agent, [8] This liquid acetylenic endothermic compound may be decomposed by mild shock, and when heated under confinement, it decomposes with explosive violence and may detonate. Addition of 20—30 wt% of toluene makes propargyl bromide insensitive in laboratory impact and confinement tests. [9]
Propargylamine is an organic compound with the formula HC≡CCH 2 NH 2.It is a colorless, odorless liquid that is used as a precursor to other compounds. [1] Propargyl amines are produced by reactions of amines with propargyl halides.
Propargyl chloride is an organic compound with the formula HC 2 CH 2 Cl. It is a colorless liquid and a lacrymator. [2] It is an alkylating agent that is used in ...
The 2-propynyl group is also known as a propargyl group, and has the structure HC≡C−CH 2 –R. [3] References
Organostannane addition is reaction involving the nucleophilic addition of an allyl-, allenyl-, or propargyl-stannane to an aldehyde, imine, or (in rare cases) a ketone. [1] This reaction is widely used for carbonyl allylation.
Rasagiline, sold under the brand name Azilect among others, is a medication which is used in the treatment of Parkinson's disease. [2] [6] It is used as a monotherapy to treat symptoms in early Parkinson's disease or as an adjunct therapy in more advanced cases. [7]