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Cobalt poisoning is intoxication caused by excessive levels of cobalt in the body. Cobalt is an essential element for health in animals in minute amounts as a component of vitamin B 12 . A deficiency of cobalt, which is very rare, is also potentially lethal, leading to pernicious anemia .
B 12 deficiency caused by Helicobacter pylori was positively correlated with CagA positivity and gastric inflammatory activity, rather than gastric atrophy. [131] Medications: long-term use of certain medications can result in poor absorption of dietary vitamin B 12. [1] These include medications to treat heartburn, and metformin to treat diabetes.
Iron: common simple anemia (iron deficiency), results in the loss of functional heme proteins (hemoglobin, myoglobin, etc.), which are responsible for oxygen transport or utilization of oxygen. Pernicious anemia comes from a lack of vitamin B-12 (which contains a cobalt complex called cobalamin), which then in turn interferes with the function ...
"B12" and "Cbl" redirect here. For other uses of B12, see B12 (disambiguation). For the musical group, see Carbon Based Lifeforms. Pharmaceutical compound Vitamin B12 General skeletal formula of cobalamins Stick model of cyanocobalamin (R = CN) based on the crystal structure Clinical data Other names Vitamin B12, vitamin B-12, cobalamin AHFS / Drugs.com Monograph MedlinePlus a605007 License ...
12 deficiency except in the presence of cyanide toxicity. [7] [8] [2] The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer. [9] [5] It is used by mouth, by injection into a muscle, or as a nasal spray. [5] [6] Cyanocobalamin is generally well tolerated. [10]
In humans most cobalt is found in Vitamin B12.A cobalt atom is visible in the center in this diagram. Cobalt is essential to the metabolism of all animals.It is a key constituent of cobalamin, also known as vitamin B 12, the primary biological reservoir of cobalt as an ultratrace element.
Common side effects may include joint pain, rash, vomiting, and headache. [4] Serious side effects may include heart attacks, stroke, increased cancer growth, or pure red cell aplasia. [2] It is unclear if use is safe during pregnancy. [5] [6] They work similar to naturally occurring erythropoietin. [1]
A few elements have been found to have a pharmacologic function in humans (and possibly in other living things as well; the phenomenon has not been widely studied). In these, a normally nonessential element can treat a disease (often a micronutrient deficiency). An example is fluorine, which reduces the effects of iron deficiency in rats.