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Voluntarily withdrawn from US market because of risk of Progressive multifocal leukoencephalopathy (PML). Returned to market July 2006. Nefazodone: 2004 Europe, Australia, New Zealand and Canada [35] [36] [37] Branded version withdrawn by originator in several countries in 2007 for hepatotoxicity. Generic versions available. Still available in ...
Rolaids is an American brand of calcium and magnesium-based antacid produced by Procter & Gamble.It was invented by American chemist Irvine W. Grote in the late 1920s, and originated with manufacturing in Chattanooga, Tennessee, under one of Chattem's forerunner companies, which manufactured the brand for Warner-Lambert; Warner-Lambert merged with Pfizer in 2000.
Bromo-Seltzer is a brand of antacid formulated to relieve pain occurring together with heartburn, upset stomach, or acid indigestion. It originally contained sodium bromide and acetanilide, both toxic substances which were eventually removed.
In November 2010, Mylanta was voluntarily recalled [2] due to what is described as some labelling concerns. According to sources within the company at that time, these concerns stemmed from the fact that small traces of alcohol were found in the flavoring agents of the liquid version of the antacid which was not disclosed on the labelling itself, and that the problem would be rectified "shortly".
The market for Zantac [15] and its competitors was described in 2005 as 13.5 billion US dollars. [ 16 ] The product's problem was described by The New York Times as being "that a potential cancer-causing contaminant can build up in the drug when stored for long periods."
A minority of the time the acetyl group is removed from the amine, producing carcinogenic p-phenetidine. This reaction is quite rare, however, as evidenced by the fact that the drug was on the market for almost 100 years before a statistical link was established, when Canada, followed by the United States, withdrew it from the market.
The U.S. Food and Drug Administration (FDA) issued a warning letter to doctors, [7] and cisapride was voluntarily removed from the U.S. market on July 14, 2000. Its use in Europe has also been limited. [5] It was banned in India and in the Philippines in 2011. [8]
Glaxo Wellcome removed troglitazone from the market in Britain on December 1, 1997. [8] Glaxo Wellcome had licensed the drug from Sankyo Company of Japan and had sold it in Britain from October 1, 1997. [16] [17] On May 17, 1998, a 55-year-old patient named Audrey LaRue Jones died of acute liver failure after taking troglitazone.
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