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Methylene blue has been described as "the first fully synthetic drug used in medicine." Methylene blue was first prepared in 1876 by German chemist Heinrich Caro. [69] Its use in the treatment of malaria was pioneered by Paul Guttmann and Paul Ehrlich in 1891. During this period before the first World War, researchers like Ehrlich believed that ...
The most effective treatment for severe (grade III–IV) encephalopathy is an intravenous solution of methylene blue, which appears to shorten the duration of encephalopathy; the exact mechanism of action of methylene blue is unclear. In some cases, methylene blue may be used as a prophylaxis before further doses of ifosfamide are administered.
Chromoendoscopy is a medical procedure wherein dyes (often the same stains used in histology) are instilled into the gastrointestinal tract at the time of visualization with fibre-optic endoscopy. The purpose of chromoendoscopy is chiefly to enhance the characterization of tissues , although dyes may be used for other functional purposes.
Wright's stain is a hematologic stain that facilitates the differentiation of blood cell types. It is classically a mixture of eosin (red) and methylene blue dyes. It is used primarily to stain peripheral blood smears, urine samples, and bone marrow aspirates, which are examined under a light microscope.
Treatment is generally with oxygen therapy and methylene blue. [3] Other treatments may include vitamin C, exchange transfusion, and hyperbaric oxygen therapy. [3] Outcomes are generally good with treatment. [3] Methemoglobinemia is relatively uncommon, with most cases being acquired rather than genetic. [3]
New methylene blue (also NMB) [clarify] is an organic compound of the thiazine class of heterocycles. It is used as a stain and as an antimicrobial agent. It is classified as an azine dye, and the chromophore is a cation, the anion is often unspecified.
The NHS hopes the device, made by medical tech firm Endoscope-i Ltd, could eventually be used in any health service setting following a trial in the West Midlands, meaning people can get tested ...
Additional studies have found that the use of methylene blue during pregnancy is associated with a high risk of small intestinal atresia, which can be fatal to the fetus. [24] It is recommended that treatment with methylene blue requires two doses before being deemed ineffective. If symptoms of methemoglobinemia are still present after the ...
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