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Methylene blue has been described as "the first fully synthetic drug used in medicine." Methylene blue was first prepared in 1876 by German chemist Heinrich Caro. [69] Its use in the treatment of malaria was pioneered by Paul Guttmann and Paul Ehrlich in 1891. During this period before the first World War, researchers like Ehrlich believed that ...
In the European Union, the combination is indicated for the treatment of COVID‑19 in people aged twelve years of age and older weighing at least 40 kilograms (88 lb) who do not require supplemental oxygen and who are at high increased risk of progressing to severe COVID‑19; [10] and for the prevention of COVID‑19 in people aged twelve years of age and older weighing at least 40 kilograms ...
Ivermectin, a medication used to treat parasitic infections, was suggested as a possible COVID-19 treatment in an online preprint which utilized a flawed statistical methodology. [159] Importantly, the concentration of the drug that was required to achieve the antiviral effects observed in cell culture was several times higher than what can be ...
This registry based, multi-center, multi-country data provide provisional support for the use of ECMO for COVID-19 associated acute hypoxemic respiratory failure. Given that this is a complex technology that can be resource intense, guidelines exist for the use of ECMO during the COVID-19 pandemic. [85] [86] [87]
Notably, methylene blue is used as as the main treatment for methemoglobinemia, however in G6PD individuals, methylene blue may cause further oxidative stress and that may induce or worsen hemolysis in those with methemoglobinemia [1]. Hemolytic anemia may also occur secondarily due to thrombotic microangiopathy after exposure to certain drugs.
The National Institutes of Health (NIH) COVID-19 Treatment Guidelines states "there is insufficient evidence to recommend either for or against the use of zinc for the treatment of COVID-19" and that "the Panel recommends against using zinc supplementation above the recommended dietary allowance for the prevention of COVID-19, except in a ...
A breath test with the SpiroNose device, made by the Dutch company Breathomix, [1] has been developed and tested in collaboration with the Leiden University Medical Center (LUMC), Franciscus Gasthuis & Vlietland and the GGD Amsterdam. The breath test has been validated as a pre-screening test for people who have no or mild symptoms of COVID-19.
[23] [24] The vaccine technology, for antigen production and use, is given patent-free to manufacturers, although Baylor College receives a fee. [ 17 ] [ 25 ] [ 26 ] The evaluation of adjuvant components for use in a RBD based vaccine was partially enabled by NIH funding [ 27 ] along with prior funding to support development of the CpG adjvuant ...
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