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Heinz bodies are associated with the consumption of paracetamol (acetaminophen), garlic, [11] [12] and onions by cats, [13] dogs, and various primates. Thiosulfate compounds in the flesh of onions have been identified as the cause.
Methylene blue has been described as "the first fully synthetic drug used in medicine." Methylene blue was first prepared in 1876 by German chemist Heinrich Caro. [69] Its use in the treatment of malaria was pioneered by Paul Guttmann and Paul Ehrlich in 1891. During this period before the first World War, researchers like Ehrlich believed that ...
The synthetic dye methylene blue, containing the structure, was described in 1876. Many water-soluble phenothiazine derivatives, such as methylene blue, methylene green, thionine, and others, can be electropolymerized into conductive polymers used as electrocatalysts for NADH oxidation in enzymatic biosensors and biofuel cells. [10] [11] [12]
New methylene blue (also NMB) [clarify] is an organic compound of the thiazine class of heterocycles. It is used as a stain and as an antimicrobial agent. It is classified as an azine dye, and the chromophore is a cation, the anion is often unspecified.
Methylene blue is given as a 1% solution (10 mg/ml) 1 to 2 mg/kg administered intravenously slowly over five minutes. Although the response is usually rapid, the dose may be repeated in one hour if the level of methemoglobin is still high one hour after the initial infusion.
methimazole – used in treatment of hyperthyroidism; methocarbamol - muscle relaxant used to reduce muscle spasms associated with inflammation, injury, intervertebral disc disease, and certain toxicities; metoclopramide – potent antiemetic, secondarily as a prokinetic; metronidazole – antibiotic against anaerobic bacteria
[21] [24] Treatment with oxygen and intravenous methylene blue frustrates visual confirmation further as methylene blue itself is, as its name suggests, a blue dye; the patient's changes in different shades of blue notwithstanding, it is an effective antidote by way of catalyzing the production of the enzyme responsible for reducing the ...
The methylene blue allows the methaemoglobin to be converted to haemoglobin. Supportive treatment is also usually provided, depending on the severity of the toxicity, that resulted in the anaemia. [11] Ascorbic acid is used to treat methemoglobinemia, a symptom of naphthalene poisoning and is used when methylene blue is not available, or in ...
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