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The most important inference derived from the steady state equation and the equation for fractional change over time is that the elimination rate constant (k e) or the sum of rate constants that apply in a model determine the time course for change in mass when a system is perturbed (either by changing the rate of inflow or production, or by ...
The other elimination pathways are less important in the elimination of drugs, except in very specific cases, such as the respiratory tract for alcohol or anaesthetic gases. The case of mother's milk is of special importance. The liver and kidneys of newly born infants are relatively undeveloped and they are highly sensitive to a drug's toxic ...
In pharmacology, clearance is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [ 1 ] The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time.
The next step in cancer immunoediting is the equilibrium phase, during which tumor cells that have escaped the elimination phase and have a non-immunogenic phenotype are selected for growth. Lymphocytes and IFN-gamma exert a selection pressure on tumor cells which are genetically unstable and rapidly mutating.
Elimination theory culminated with the work of Leopold Kronecker, and finally Macaulay, who introduced multivariate resultants and U-resultants, providing complete elimination methods for systems of polynomial equations, which are described in the chapter on Elimination theory in the first editions (1930) of van der Waerden's Moderne Algebra.
Excretion is elimination of metabolic waste, which is an essential process in all organisms. In vertebrates , this is primarily carried out by the lungs , kidneys , and skin . [ 1 ] This is in contrast with secretion , where the substance may have specific tasks after leaving the cell .
Drug elimination, clearance of a drug or other foreign agent from the body; Elimination, the destruction of an infectious disease in one region of the world as opposed to its eradication from the entire world; Hazard elimination, the most effective type of hazard control; Elimination (pharmacology), processes by which a drug is eliminated from ...
The discovery of dephosphorylation came from a series of experiments examining the enzyme phosphorylase isolated from rabbit skeletal muscle. In 1955, Edwin Krebs and Edmond Fischer used radiolabeled ATP to determine that phosphate is added to the serine residue of phosphorylase to convert it from its b to a form via phosphorylation. [3]