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Some studies show it can reduce DHT but doesn’t help with hair growth. Other studies show that topical finasteride is as effective as oral finasteride after 18 months of treatment.
Finasteride is a 5α-reductase inhibitor and therefore an antiandrogen. [10] It works by decreasing the production of dihydrotestosterone (DHT) by about 70%. [6] In addition to DHT, finasteride also inhibits the production of several anticonvulsant neurosteroids including allopregnanolone, androstanediol, and tetrahydrodeoxycorticosterone. [11]
Finasteride is one of two 5-alpha reductase inhibitors, along with dutasteride. 5-alpha reductase is an enzyme that your body eventually converts into a hormone called dihydrotestosterone (DHT).
5-alpha reductase blockers reduce DHT levels, slowing down, stopping, or reversing the effects of male pattern baldness. ... Finasteride has been shown to lower the overall risk of prostate cancer ...
Finasteride (brand names Proscar, Propecia) inhibits the function of two of the isoenzymes (types 2 and 3) of 5α-reductase. [6] [7] It decreases circulating DHT levels by up to about 70%. [8] Dutasteride (brand name Avodart) inhibits all three 5α-reductase isoenzymes and can decrease DHT levels by 95%.
Finasteride potently inhibits 5α-R2 at a mean inhibitory concentration IC 50 of 69 nM, but is less effective with 5α-R1 with an IC 50 of 360 nM. [21] Finasteride decreases mean serum level of DHT by 71% after 6 months, [22] and was shown in vitro to inhibit 5α-R3 at a similar potency to 5α-R2 in transfected cell lines. [2]
Research shows that using finasteride as recommended lowers serum DHT levels (the amount of DHT in your bloodstream) by more than 70 percent. This reduction in DHT can slow, or even stop, your ...
This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase.This enzyme is responsible for the conversion of the androgen hormone testosterone into the more potent dihydrotestosterone (DHT) and is essential for the production of neurosteroids like allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol from ...
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