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In gout, probenecid competitively inhibits the reabsorption of uric acid through the organic anion transporter (OAT) at the proximal tubules. This leads to preferential reabsorption of probenecid back into plasma and excretion of uric acid in urine, [ 6 ] thus reducing blood uric acid levels and reducing its deposition in various tissues.
A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism.In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for treatment of hyperuricemia and related medical conditions including gout. [1]
Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins , endogenous signaling molecules known to cause these symptoms.
NSAIDs are often used in treatment of acute gout attacks. COX-2 inhibitors appear to work as well as nonselective NSAIDs, such as aspirin. [9] They have not been compared to other treatment options such as colchicine or glucocorticoids. [9] [10]
There are so many potential health problems that can afflict the feet ? like ingrown toenails, bunions, blisters, and even gout. 11 easy, natural ways to treat nearly all of your foot problems ...
Do you sometimes have severe, unexplained pain in your joints, particularly in your big toe, ankle, or knee? The post Managing Out-of-Control Chronic Gout: Going Beyond Oral Treatments appeared ...
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