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  2. Interferon type I - Wikipedia

    en.wikipedia.org/wiki/Interferon_type_I

    The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16 ...

  3. Interferon gamma - Wikipedia

    en.wikipedia.org/wiki/Interferon_gamma

    Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. [5] The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. [6]

  4. Interferon - Wikipedia

    en.wikipedia.org/wiki/Interferon

    The type II IFN (IFN-γ) gene was also isolated around this time. [83] Interferon was first synthesized manually at Rockefeller University in the lab of Dr. Bruce Merrifield, using solid phase peptide synthesis, one amino acid at a time. He later won the Nobel Prize in chemistry.

  5. Interferon Lambda 4 - Wikipedia

    en.wikipedia.org/wiki/Interferon_Lambda_4

    101180976 n/a Ensembl ENSG00000272395 n/a UniProt K9M1U5 n/a RefSeq (mRNA) NM_001276254 n/a RefSeq (protein) NP_001263183 n/a Location (UCSC) Chr 19: 39.25 – 39.25 Mb n/a PubMed search n/a Wikidata View/Edit Human Interferon lambda 4 (gene symbol: IFNL4) is one of the most recently discovered human genes and the newest addition to the interferon lambda protein family. This gene encodes the ...

  6. Interferon-gamma receptor - Wikipedia

    en.wikipedia.org/wiki/Interferon-gamma_receptor

    The human interferon-gamma receptor complex consists the heterodimer of two chains: IFNGR1 and IFNGR2. [2] [3] In unstimulated cells, these subunits are not preassociated with each other but rather associate through their intracellular domains with inactive forms of specific Janus family kinases (Jak1 and Jak2).

  7. Interferon alfa - Wikipedia

    en.wikipedia.org/wiki/Interferon_alfa

    Interferon alfa or HuIFN-alpha-Le, trade name Multiferon, is a pharmaceutical drug composed of natural interferon alpha (IFN-α), obtained from the leukocyte fraction of human blood following induction with Sendai virus. Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography.

  8. Interferon type III - Wikipedia

    en.wikipedia.org/wiki/Interferon_type_III

    The similarity between IFN-λ2 and IFN-λ3 is approximately 96%, similarity of IFNλ1 to IFNλ 2/3 is around 81%. [2] Lowest similarity is found between IFN-λ4 and IFN-λ3 - only around 30%. [ 8 ] [ 9 ] Unlike type I interferon group, which consist of only one exon, type III interferons consist of multiple exons.

  9. Interferon beta-1a - Wikipedia

    en.wikipedia.org/wiki/Interferon_beta-1a

    Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS). [5] It is produced by mammalian cells, while interferon beta-1b is produced in modified E. coli. [6]