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Bimatoprost is a structural analog of prostaglandin F 2α (PGF 2α). Like other PGF 2α analogs such as travoprost, latanoprost and tafluprost, it increases the outflow of aqueous fluid from the eye and lowers intraocular pressure.
Latanoprost, sold under the brand name Xalatan among others, is a medication used to treat increased pressure inside the eye (intraocular pressure). [5] This includes ocular hypertension and open-angle glaucoma. [5] Latanaprost is applied as eye drops to the eyes. [5] Onset of effects is usually within four hours, and they last for up to a day. [5]
5737 19220 Ensembl ENSG00000122420 ENSMUSG00000028036 UniProt P43088 P43117 RefSeq (mRNA) NM_000959 NM_001039585 NM_008966 RefSeq (protein) NP_000950 NP_001034674 NP_032992 Location (UCSC) Chr 1: 78.3 – 78.54 Mb Chr 3: 151.5 – 151.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Prostaglandin F receptor (FP) is a receptor belonging to the prostaglandin (PG) group of receptors ...
This work led to the development of prodrugs of PGF2α, including latanoprost, an isopropyl analogue of PGF2α, approved by the FDA in 1996, bimatoprost and travoprost, both approved in 2001, and tafluprost, approved in 2012. [1]
Prostaglandin F 2α (PGF 2α in prostanoid nomenclature), pharmaceutically termed dinoprost, is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. [1]
Latanoprost: Xalatan: Increased USO (uveoscleral outflow ) Once daily: 25-32%: pigmentation of eyelashes, eyelid skin pigmentation, hyperemia (red eye), flu-like symptoms (joint/muscle pain and headache) Bimatoprost: Lumigan: Increased USO (uveoscleral outflow ) Once daily
In treatment of glaucoma (as in bimatoprost ophthalmic solution, a synthetic prostamide analog with ocular hypotensive activity) (PGF 2α) To treat erectile dysfunction or in penile rehabilitation following surgery (PGE1 as alprostadil). [29] To measure erect penis size in a clinical environment [30] To treat egg binding in small birds [31]
Bimatoprost/timolol, sold under the brand name Ganfort, is a medication for the treatment of certain conditions involving high pressure in the eyes, specifically open angle glaucoma and ocular hypertension. [1] [3] It is available as eye drops. [1] [3] It was approved for medical use in the European Union in May 2006. [3]