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Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.. HNPCC includes (and was once synonymous with) [1] Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. [2]
The William Lynch speech, also known as the Willie Lynch letter, is an address purportedly delivered by a William Lynch (or Willie Lynch) to an audience on the bank of the James River in Virginia in 1712 regarding control of slaves within the colony. [1] In recent years, it has been widely exposed as a hoax. [2] [3]
Under the name constitutional mismatch repair-deficiency (CMMR-D), it has been mapped to MLH1, MSH2, MSH6 or PMS2. [2] Monoallelic mutations of these genes are observed in the condition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer, while biallelic mutations are observed in CMMR-D. [3] People expressing the HNPCC (which itself is considered autosomal dominant) trait are ...
Potocki–Shaffer syndrome; Potter sequence; Prader–Willi syndrome; Pre-excitation syndrome; Precordial catch syndrome; Premenstrual syndrome; Presumed ocular histoplasmosis syndrome; Pretzel syndrome; Primary pigmented nodular adrenocortical disease; Primrose syndrome; Progeroid syndromes; Progressive supranuclear palsy; Prolonged grief ...
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An eponymous disease is a disease, disorder, condition, or syndrome named after a person, usually the physician or other health care professional who first identified the disease; less commonly, a patient who had the disease; rarely, a literary character who exhibited signs of the disease or an actor or subject of an allusion, as characteristics associated with them were suggestive of symptoms ...
To indicate that somehow the Willie Lynch letter is inaccurate for indicating there was a division of house and field slaves is proposterous given that it is a known fact that there was a division of labor and individuals in this manner that still has repercussions today.
Two Americans during this era are generally credited for coining the phrase: Charles Lynch (1736–1796) and William Lynch (1742–1820), both of whom lived in Virginia in the 1780s. [8] Charles Lynch is more likely to have coined the phrase, as he was known to have used the term in 1782, while William Lynch is not known to have used the term ...