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Mascot is a software search engine that uses mass spectrometry data to identify proteins from peptide sequence databases. [ 1 ] [ 2 ] Mascot is widely used by research facilities around the world. Mascot uses a probabilistic scoring algorithm for protein identification that was adapted from the MOWSE algorithm.
These methods determined the mass of peptides using mass spectrometry, and then used the mass to search protein databases to identify the proteins [3] [4] In 1999 a more complex program was released called Mascot that integrated three types of protein/database searches: peptide molecular weights, tandem mass spectrometry from one or more ...
Byonic is a database search algorithm released in 2011 by Protein Metrics Inc. with original developments at PARC. [2] It searches MS/MS data from all types of instruments and internally employs the program Combyne, [3] which combines peptide identifications to produce protein scores and identification probabilities. CHIMERYS Proprietary
The MASCOT software uses an algorithm that looks for significant peptide sequence homology to present the most statistically likely protein in the sample, based on the results. In performing the search, you much choose a database to go through.
RNA-binding protein database: Protein-protein and other molecular interactions Database of Interacting Proteins: Univ. of California: Protein-protein and other molecular interactions IntAct [21] EMBL-EBI: open-source database for molecular interactions Protein-protein and other molecular interactions String
Their AI program – the AlphaFold Protein Structure Database – has been used by at least 2 million researchers around the world. It acts as a “Google search” for protein structures ...
The software evaluates protein sequences from a database to compute the list of peptides that could result from each. The peptide's intact mass is known from the mass spectrum, and Sequest uses this information to determine the set of candidate peptides sequences that could meaningfully be compared to the spectrum by including only those near ...
The structures of TMT tags are publicly available through the unimod database at unimod.org and hence, mass spectrometry software such as Mascot are able to account for the tag masses. Additionally, as of version 2.2, Mascot has the capability to quantify using TMT and other isobaric mass tags without the use of additional software. Intuitively ...