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Post-polio syndrome (PPS, poliomyelitis sequelae) is a group of latent symptoms of poliomyelitis (polio), occurring in more than 80% of polio infections. The symptoms are caused by the damaging effects of the viral infection on the nervous system and typically occur 15 to 30 years after an initial acute paralytic attack.
Remarkably, there have been no toxic side effects with PVS-RIPO whatsoever, even at the highest possible dose (10 billion infectious virus particles). The potential value of PVSRIPO was the focus of a 2015 story on 60 Minutes. [4] In May 2016, the US Food and Drug Administration granted it breakthrough therapy designation for glioblastoma. [2]
Poliomyelitis (/ ˌ p oʊ l i oʊ ˌ m aɪ ə ˈ l aɪ t ɪ s / POH-lee-oh-MY-ə-LY-tiss), commonly shortened to polio, is an infectious disease caused by the poliovirus. [1] Approximately 75% of cases are asymptomatic; [5] mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia.
For roughly 80 years, she has coped with the aftermath of a polio infection, including the late effects of polio, called post-polio syndrome. She now needs a wheelchair or mobility scooter to get ...
Oral polio vaccine contains live attenuated (weakened) strains of the three serotypes of poliovirus. Passaging the virus strains in monkey kidney epithelial cells introduces mutations in the viral IRES, and hinders (or attenuates) the ability of the virus to infect nerve tissue. [26]
Polio is “shorthand for poliomyelitis, a disease of the central nervous system caused by infection with poliovirus,” Dr. Richard Lloyd, professor of molecular virology and microbiology at ...
A few could contract meningitis if the polio virus attacks the covering of the spinal cord or brain. Polio is fatal for 2%-10% of those paralyzed or between 1 in 2,000 to 1 in 10,000 of those ...
A neurotropic virus is said to be neuroinvasive if it is capable of accessing or entering the nervous system and neurovirulent if it is capable of causing disease within the nervous system. Both terms are often applied to central nervous system infections, although some neurotropic viruses are highly neuroinvasive for the peripheral nervous ...