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2. Asymmetric cell division - Wikipedia

   en.wikipedia.org/wiki/Asymmetric_cell_division

   In normal stem and progenitor cells, asymmetric cell division balances proliferation and self-renewal with cell-cycle exit and differentiation. Disruption of asymmetric cell division leads to aberrant self-renewal and impairs differentiation, and could therefore constitute an early step in the tumorogenic transformation of stem and progenitor ...

3. Immortal DNA strand hypothesis - Wikipedia

   en.wikipedia.org/wiki/Immortal_DNA_strand_hypothesis

   The immortal DNA strand hypothesis was proposed in 1975 by John Cairns as a mechanism for adult stem cells to minimize mutations in their genomes. [1] This hypothesis proposes that instead of segregating their DNA during mitosis in a random manner, adult stem cells divide their DNA asymmetrically, and retain a distinct template set of DNA strands (parental strands) in each division.

4. Metabolic regulation of hematopoiesis - Wikipedia

   en.wikipedia.org/wiki/Metabolic_regulation_of...

   All adult stem cells can undergo two types of division: symmetric and asymmetric. When a cell undergoes symmetric division, it can either produce two differentiated cells or two new stem cells. When a cell undergoes asymmetric division, it produces one stem and one differentiated cell. Production of new stem cells is necessary to maintain this ...

5. Stem cell - Wikipedia

   en.wikipedia.org/wiki/Stem_cell

   To ensure self-renewal, stem cells undergo two types of cell division (see Stem cell division and differentiation diagram). Symmetric division gives rise to two identical daughter cells both endowed with stem cell properties. Asymmetric division, on the other hand, produces only one stem cell and a progenitor cell with limited self-renewal ...

6. Jürgen Knoblich - Wikipedia

   en.wikipedia.org/wiki/Jürgen_Knoblich

   Aurora kinase A is often over-expressed in tumor cells, alongside other molecules that also play a role in the process of asymmetric cell division. Since stem cell mitosis is a highly conserved process, results found in fruit flies can be transferred to humans and thereby help to gain insights into general tumor neogenesis [16]

7. Adult stem cell - Wikipedia

   en.wikipedia.org/wiki/Adult_stem_cell

   A stem cell possesses two properties: . Self-renewal is the ability to go through numerous cycles of cell division while still maintaining its undifferentiated state. Stem cells can replicate several times and can result in the formation of two stem cells, one stem cell more differentiated than the other, or two differentiated cells.