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  2. CD4 - Wikipedia

    en.wikipedia.org/wiki/CD4

    Image of CD4 co-receptor binding to MHC (Major Histocompatibility Complex) non-polymorphic region. In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells.

  3. Major histocompatibility complex - Wikipedia

    en.wikipedia.org/wiki/Major_histocompatibility...

    Antigen presentation: MHC molecules bind to both T cell receptor and CD4/CD8 co-receptors on T lymphocytes, and the antigen epitope held in the peptide-binding groove of the MHC molecule interacts with the variable Ig-Like domain of the TCR to trigger T-cell activation [26]

  4. Co-receptor - Wikipedia

    en.wikipedia.org/wiki/Co-receptor

    The CD family of co-receptors are a well-studied group of extracellular receptors found in immunological cells. [4] The CD receptor family typically act as co-receptors, illustrated by the classic example of CD4 acting as a co-receptor to the T cell receptor (TCR) to bind major histocompatibility complex II (MHC-II). [5]

  5. CD8.4 - Wikipedia

    en.wikipedia.org/wiki/CD8.4

    The extracellular and transmembrane part of the coreceptor is from wild-type CD8 coreceptor, whereas the intracellular domain from CD4 coreceptor. [1] This model was created to examine role of coreceptor coupling to Lck (lymphocyte-specific protein tyrosine kinase) [1] as the CD4 and CD8 coreceptors have an Lck-binding site in their ...

  6. SIP (software) - Wikipedia

    en.wikipedia.org/wiki/SIP_(software)

    SIP is an open source software tool used to connect computer programs or libraries written in C or C++ with the scripting language Python.It is an alternative to SWIG.. SIP was originally developed in 1998 for PyQt — the Python bindings for the Qt GUI toolkit — but is suitable for generating bindings for any C or C++ library.

  7. CD4 immunoadhesin - Wikipedia

    en.wikipedia.org/wiki/CD4_immunoadhesin

    CD4 immunoadhesin was first developed in the mid-1990s as a potential therapeutic agent and treatment for HIV/AIDS. The protein is a fusion of the extracellular domain of the CD4 receptor and the Fc domain of human immunoglobulin G (IgG), the most abundant antibody isotype in the human body. [1]

  8. Tyrosin-protein kinase Lck - Wikipedia

    en.wikipedia.org/wiki/Tyrosin-protein_kinase_Lck

    The antigen-presenting cells (APC) expose on their surface a fraction of the antigen that is recognized either from CD8+ T cells or CD4+ T cells. This binding leads to the activation of TCR signaling cascade in which the immunoreceptor tyrosine-based activation motifs (ITAM) located in the CD3-zeta chains (ζ-chains) of the TCR complex, are ...

  9. Envelope glycoprotein GP120 - Wikipedia

    en.wikipedia.org/wiki/Envelope_glycoprotein_GP120

    Since CD4 receptor binding is the most obvious step in HIV infection, gp120 was among the first targets of HIV vaccine research. Efforts to develop HIV vaccines targeting gp120, however, have been hampered by the chemical and structural properties of gp120, which make it difficult for antibodies to bind to it. gp120 can also easily be shed from the surface of the virus and captured by T cells ...