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Analgesic nephropathy is injury to the kidneys caused by analgesic medications such as aspirin, bucetin, phenacetin, and paracetamol.The term usually refers to damage induced by excessive use of combinations of these medications, especially combinations that include phenacetin.
Tridimensional model of the chemical structure of aspirin. Aspirin causes several different effects in the body, mainly the reduction of inflammation, analgesia (relief of pain), the prevention of clotting, and the reduction of fever. Much of this is believed to be due to decreased production of prostaglandins and TXA2.
[55] [56] Use of aspirin during dengue fever is not recommended owing to increased bleeding tendency. [57] People with kidney disease, hyperuricemia, or gout should not take aspirin because it inhibits the kidneys' ability to excrete uric acid, and thus may exacerbate these conditions.
As a result, the researchers concluded that people who are already taking a low-dose aspirin keep on taking it unless they have significant risk factors for aspirin-related bleeding.
Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. [10] For pain or fever, effects typically begin within 30 minutes. [10] Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. [10] One common adverse effect is an upset ...
Aspirin also decreases your body’s natural protective effects against stomach acid, Alan says. ... While aspirin is an over-the-counter medication, it does come with a risk of side effects ...
Many Americans 60 years and older still take daily aspirin to help prevent cardiovascular disease, even though it can pose significant health risks.
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
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