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Diabetic nephropathy is the most common cause of end-stage renal disease and is a serious complication that affects approximately one quarter of adults with diabetes in the United States. [ 13 ] [ 14 ] Affected individuals with end-stage kidney disease often require hemodialysis and eventually kidney transplantation to replace the failed kidney ...
Secondary causes of nephrotic syndrome have the same histologic patterns as the primary causes, though they may exhibit some differences suggesting a secondary cause, such as inclusion bodies. [24] They are usually described by the underlying cause, such as: [citation needed] Diabetic nephropathy: is a complication that occurs in some diabetics ...
Retinopathy is the most common cause of blindness among non-elderly adults in the developed world. Diabetic nephropathy, damage to the kidney due to increased glomerular pressure and hyperfiltration can lead to end-stage chronic kidney disease that may require renal dialysis. [27] In most parts of the world, diabetes mellitus is the leading ...
Diabetic nephropathy: A condition that is secondary to diabetes mellitus that may cause damage in filtration pathways in kidneys. This can cause an increase of fluid pressure within the glomeruli, thus causing their hypertrophy, or breakdown. [10] Amyloidosis: This disease causes the buildup abnormal proteins called amyloid fibrils. Depositions ...
Diabetic nephropathy is a major cause of chronic kidney disease, accounting for over 50% of patients on dialysis in the United States. [32] Diabetic neuropathy, damage to nerves, manifests in various ways, including sensory loss, neuropathic pain, and autonomic dysfunction (such as postural hypotension, diarrhoea, and erectile dysfunction). [22]
The most common causes of CKD are diabetes mellitus, hypertension, and glomerulonephritis. [43] [44] About one of five adults with hypertension and one of three adults with diabetes have CKD. If the cause is unknown, it is called idiopathic. [45]
The most obvious cause is a kidney or systemic disorder, including amyloidosis, [2] polycystic kidney disease, [3] electrolyte imbalance, [4] [5] or some other kidney defect. [2] The major causes of acquired nephrogenic diabetes insipidus that produce clinical symptoms (e.g., polyuria) in the adult are lithium toxicity and high blood calcium.
There are three main mechanisms to cause proteinuria: [5] Due to disease in the glomerulus; Because of increased quantity of proteins in serum (overflow proteinuria) Due to low reabsorption at proximal tubule (Fanconi syndrome) Proteinuria can also be caused by certain biological agents, such as bevacizumab (Avastin) used in cancer treatment ...