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Crohn's disease is believed to be caused by a dysregulated immune response to gut bacteria, though the exact mechanism is unknown. This is evidenced by the disease's links to genes involved in bacteria defense and its occurrence in the ileum and colon, the most bacteria-dense segments of the intestine. [23]
The disease caused by Y. enterocolitica is called yersiniosis. Yersinia may be associated with Crohn's disease, an inflammatory autoimmune condition of the gut. Iranian people with Crohn's disease were more likely to have had earlier exposure to refrigerators at home, [6] consistent with its unusual ability to thrive at low temperatures.
It has long been suspected as a causative agent in Crohn's disease in humans, [4] [5] but studies have been unable to show definite correlation. [6] One study has argued that the presence of antibodies against Mycobacterium avium subspecies paratuberculosis is associated with increased propensity of patients with Crohn's disease to receive ...
As of 2019, about 4.9 million people globally were living with an inflammatory bowel disease (IBD) such as Crohn’s disease. Scientists are still unclear as to the exact cause of Crohn’s ...
Autoimmune causes of enteritis such as Crohn's disease require significant chronic treatment to avoid nutritional deficiencies, cancer, bacterial overgrowth, and other complications. [5] Some patients with mild forms of the disease may not need treatment, but a majority of people with Crohn's disease require glucocorticoid medications. [24]
In Crohn's disease, surgery involves removing the worst inflamed segments of the intestine and connecting the healthy regions, but unfortunately, it does not cure Crohn's or eliminate the disease. At some point after the first surgery, Crohn's disease can recur in the healthy parts of the intestine, usually at the resection site. [76] (For ...
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