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Ketamine-assisted psychotherapy (KAP) is the use of prescribed doses of ketamine as an adjunct to psychotherapy sessions. KAP shows significant potential in treating mental disorders such as treatment-resistant depression (TRD), anxiety, obsessive–compulsive disorders (OCD), post-traumatic stress disorders (PTSD), and other conditions. [1]
Ketamine is likely to be most beneficial for surgical patients when severe post-operative pain is expected, and for opioid-tolerant patients. [50] [51] Ketamine is especially useful in the pre-hospital setting due to its effectiveness and low risk of respiratory depression. [52]
As U.S. doctors scale back their use of opioid painkillers, a new option for hard-to-treat pain is taking root: ketamine, the decades-old surgical drug that is now a trendy psychedelic therapy.
Psychotherapy is an effective treatment for trauma-related disorders. A meta-analysis of treatment outcomes has shown that 67% of patients who completed treatment for PTSD no longer met diagnostic criteria for PTSD. [4] For those seeking evidence-based psychotherapy treatment, it is estimated that 22-24% will drop out of their treatment.
Similarly, the use of other drugs influenced how well ketamine and ECT worked. The re-analysis showed that 42.9% of people taking atypical antipsychotics alongside ketamine improved significantly.
Physicians also urged people not to write off ketamine for medical treatment in light of the tragedy. When doctors turn to ketamine for patients with depression, “these are patients who might ...
Esketamine, sold under the brand names Spravato (for depression) and Ketanest (for anesthesia) among others, [10][12] is the S (+) enantiomer of ketamine. [5][13] It is a dissociative hallucinogen drug used as a general anesthetic and as an antidepressant for treatment of depression. Esketamine is the active enantiomer of ketamine in terms of ...
After the publication of the NIH-run antidepressant clinical trial, clinics began opening in which the intravenous ketamine is given for depression. [5] [6] This practice is an off label use of IV ketamine in the United States, though the intranasal version of esketamine has been approved by the FDA for treatment of depression [5] [7] In 2015 there were about 60 such clinics in the US; the ...