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Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; [1] the term is typically used when referring to metastasis by a cancerous tumor. [2] The newly pathological sites, then, are metastases (mets). [3][4] It is generally distinguished from cancer invasion, which is ...
Oncology. Bone metastasis, or osseous metastatic disease, is a category of cancer metastases that result from primary tumor invasions into bones. Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing sarcoma are rare; the most common bone tumor is a metastasis. [1] Bone metastases can be classified as osteolytic ...
A malignant tumor is defined by its capacity to initiate a biological phenomenon known as the metastatic cascade, a complex multi-stage process in which cell invasion precedes further cancer progression and the formation of metastases in distant organs and tissues. Massive metastatic lesions lead to the development of organ failure.
CNS metastasis is the spread and proliferation of cancer cells from their original tumour to form secondary tumours in portions of the CNS. [1] Typically, this progression initiates when tumour cells separate from the primary tumour and insert into the bloodstream or the lymph system via intravasation. [2] Intravasation into the circulatory ...
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. [ 2 ][ 7 ] These contrast with benign tumors, which do not spread. [ 7 ] Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. [ 1 ]
A brain metastasis is a cancer that has metastasized (spread) to the brain from another location in the body and is therefore considered a secondary brain tumor. [1][2] The metastasis typically shares a cancer cell type with the original site of the cancer. [3] Metastasis is the most common cause of brain cancer, as primary tumors that ...
Malignancy. Malignancy (from Latin male 'badly' and -gnus 'born') is the tendency of a medical condition to become progressively worse; the term is most familiar as a characterization of cancer. A malignant tumor contrasts with a non-cancerous benign tumor in that a malignancy is not self-limited in its growth, is capable of invading into ...
Determining the extent to which a cancer has developed. Cancer staging is the process of determining the extent to which a cancer has grown and spread. A number from I to IV is assigned, with I being an isolated cancer and IV being a cancer that has metastasized and spread from its origin. The stage generally takes into account the size of a ...