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Overall, this systematic review demonstrates that there is currently some evidence for the therapeutic effect of B12 in the treatment of post-herpetic neuralgia (level II evidence) and the treatment of painful peripheral neuropathy (level III evidence).
One proposed treatment for neuropathic pain is vitamin B12, which is thought to alleviate pain by a number of mechanisms including promoting myelination, increasing nerve regeneration and decreasing ectopic nerve firing.
High doses of vitamin B-12, such as those used to treat a deficiency, might cause: Headache; Nausea and vomiting; Diarrhea; Fatigue or weakness; Tingling sensation in hands and feet
B12 is particularly effective in treating some types of nerve pain. It can spur cell growth to help regenerate damaged nerves and reduce chronic nerve pain. Doctors may order blood tests to check B12 levels in some patients with nerve problems.
High-dose vitamin B12 promoted neurite outgrowth and neuronal survival and increased extracellular signal-regulated kinases and Akt signaling after sciatic nerve injury. It also promoted functional recovery of nerves.
Overview. Key takeaways. Early signs. Other symptoms. Comparable conditions. When to see a doctor. Complications. Treatment. Overview: What does too much B12 feel like? Vitamin B12 is a water-soluble vitamin necessary for nervous system function, red blood cell production, and cell division.
B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review. by. Thomas Julian. 1,2,*, Rubiya Syeed. 1, Nicholas Glascow. 3, Efthalia Angelopoulou. 4 and. Panagiotis Zis. 5,* 1. Faculty of Medicine, Dentistry and Health, The University of Sheffield, Sheffield S10 2TJ, UK. 2.
Meanwhile, the high dose (1.5 mg/kg) of vitamin B12 treatment showed better effectiveness than the 0.5 mg/kg dose in TBI mice. In addition, the combination therapy with the ER stress inhibitor 4-PBA partially strengthened the neuro-protective effect of vitamin B12.
Oral administration of high-dose vitamin B 12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms. Intramuscular therapy leads to more...
One proposed treatment for neuropathic pain is vitamin B12, which is thought to alleviate pain by a number of mechanisms including promoting myelination, increasing nerve regeneration and...