Search results
Results from the WOW.Com Content Network
The overall survival rates in children with DS-ALL and DS-AML were 35.7% and 57.1%, respectively (P = .438). The overall survival rate was significantly worse in children with DS-ALL than in those with acute lymphoblastic leukemia without DS (35.71% vs 75.80%, P = .001).
Children with Down syndrome are at an increased risk of developing leukemia due to an extra copy of chromosome 21. There is a higher cure rate for this group than for the general population...
Research Spotlight: How Often Were Adults With Down Syndrome Listed as Do-Not-Resuscitate During the COVID-19 Era? Researchers found that a person with a diagnosis of Down syndrome and COVID-19 pneumonia had six times the odds of having a Do Not Resuscitate (DNR) status ordered at hospital admission.
Children with leukemia typically have a high survival rate. About 98 percent of children with or without Down syndrome who have ALL achieve remission, with 90 percent surviving 5 years or longer.
Significant progress has been made in the treatment of children with myeloid leukemia of Down syndrome (MLDS) with 5-year survival now approaching 90%.
Children with Down syndrome (DS) are at a substantially increased risk to develop acute myeloid leukemia (AML). This increase in incidence is tempered, however, by favorable overall survival rates of approximately 80%, whereas survival for non-DS children with similar leukemic subtypes is <35%.
Key Points. Treatment outcomes for relapsed or refractory ML-DS remain dismal in a contemporary treatment period (3-year OS 22%). Patients who had a long duration of first remission, achieved a second remission and underwent HSCT were most likely to survive.
For more than 6 decades we have known that children with Down syndrome (DS) have a significant risk for developing both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)...
General Information About Childhood Myeloid Malignancies. Inherited and Acquired Conditions Associated With AML and Other Myeloid Malignancies. Classification of Pediatric Myeloid Malignancies. Treatment Option Overview for Childhood AML. Special Considerations for the Treatment of Children With Cancer. Treatment of Childhood AML.
Children with Down syndrome have a 10-fold to 45-fold increased risk of leukemia when compared with children without Down syndrome. However, the ratio of acute lymphoblastic leukemia to acute myeloid leukemia (AML) is typical for childhood acute leukemia.