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The therapeutic as well as adverse effects of midazolam are due to its effects on the GABA A receptors; midazolam does not activate GABA A receptors directly but, as with other benzodiazepines, it enhances the effect of the endogenous neurotransmitter GABA on the GABA A receptors (increasing the frequency of Cl − channel opening) resulting in ...
Midazolam is the most commonly prescribed for this use because of its strong sedative actions and fast recovery time, as well as its water solubility, which reduces pain upon injection. Diazepam and lorazepam are sometimes used. Lorazepam has particularly marked amnesic properties that may make it more effective when amnesia is the desired effect.
The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.
Benzodiazepine use disorder (BUD), also called misuse or abuse, [1] is the use of benzodiazepines without a prescription and/or for recreational purposes, which poses risks of dependence, withdrawal and other long-term effects. [2] [3] Benzodiazepines are one of the more common prescription drugs used recreationally.
Sedatives — most commonly alcohol [26] but also GHB, Flunitrazepam (Rohypnol), and to a lesser extent, temazepam (Restoril), and midazolam (Versed) [27] — have been reported for their use as date rape drugs (also called a Mickey) and being administered to unsuspecting patrons in bars or guests at parties to reduce the intended victims ...
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An episode of Arrested Development called Forget-Me-Now discusses the use of drug-induced amnesia for those who have seen how magicians' tricks are performed. In the PC Game Amnesia: The Dark Descent (2010), the player character, Daniel, wakes up with amnesia in the terrifying Castle Brennenburg, and must discover the truth about his memories.
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