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A dosage of 1 mg/day oral estradiol valerate has been found to produce approximate circulating concentrations of 50 pg/mL estradiol and 160 pg/mL estrone, while a dosage of 2 mg/day results in circulating levels of 60 pg/mL estradiol and 300 pg/mL estrone. [108]
Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued) Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL; Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.
Estradiol (E2) is a medication and naturally occurring steroid hormone. [11] [12] [13] It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women.
1.38 (1.23–1.56)* 1.84 (1.69–2.00)* Estradiol/norgestrel or estradiol/drospirenone: 1.42 (1.00–2.03) Conjugated estrogens/medroxyprogesterone acetate: 2.10 (1.92–2.31)* Conjugated estrogens/norgestrel ≤0.625 mg/day CEEs >0.625 mg/day CEEs: 1.73 (1.57–1.91)* 1.53 (1.36–1.72)* 2.38 (1.99–2.85)* Tibolone alone: 1.02 (0.90–1.15 ...
The 20 cm 2 Evra contraceptive patch contains 600 μg ethinylestradiol and 6000 μg norelgestromin. [8] The Ortho Evra contraceptive patch and the Evra contraceptive patch are both intended to gradually release into the systemic circulation approximately 20 μg/day of ethinylestradiol and 150 μg/day of norelgestromin. [5] [8]
Estrogen esters are essentially inactive themselves, with esters such as estradiol valerate and estradiol sulfate having about 2% of the affinity of estradiol for the estrogen receptor. [12] Likewise, the estrogen ether mestranol (ethinylestradiol 3-methyl ether) has about 1% of the affinity of estradiol for the estrogen receptor. [ 12 ]
A combination of 20 μg/day EE and 0.25 mg/day levonorgestrel, a progestin with relatively high androgenicity, decreases SHBG levels by 50%; 30 μg/day EE and 0.25 mg/day levonorgestrel has no effect on SHBG levels; 30 μg/day EE and 0.15 mg/day levonorgestrel increases SHBG levels by 30%; and triphasic COCs containing EE and levonorgestrel ...
Diethylstilbestrol dipropionate (Cyren B) [2] Estradiol (Aquadiol, Diogyn, ... Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; ...
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