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Connective tissue disease, also known as connective tissue disorder, or collagen vascular diseases, refers to any disorder that affects the connective tissue. [1] The body's structures are held together by connective tissues, consisting of two distinct proteins : elastin and collagen .
Collagens are complex molecules that provide structure, strength, and elasticity to connective tissue. Type II and type XI collagen disorders are grouped together because both types of collagen are components of the cartilage found in joints and the spinal column, the inner ear, and the jelly-like substance that fills the eyeball (the vitreous ...
Systemic lupus erythematosus (SLE) – a major autoimmune disease of connective tissue Scurvy , caused by a deficiency of vitamin C which is necessary for the synthesis of collagen. Fibromuscular dysplasia is a disease of the blood vessels that leads to an abnormal growth in the arterial wall.
Elastin is a protein encoded by the ELN gene in humans and several other animals. Elastin is a key component in the extracellular matrix of gnathostomes (jawed vertebrates). [ 5 ] It is highly elastic and present in connective tissue of the body to resume its shape after stretching or contracting. [ 6 ]
Cutis laxa and Williams syndrome have elastic matrix defects that have been directly associated with alterations in the elastin gene. Alpha-1 antitrypsin deficiency is a genetic disorder where elastin is excessively degraded by elastase, a degrading protein released by neutrophils during the inflammatory response.
In the earlier stages of actinic elastosis, elastic fiber proliferation can be seen in the dermis. As the condition becomes more established, the collagen fibers of the papillary dermis and reticular dermis become increasingly replaced by thickened and curled fibers that form tangled masses and appear basophilic under routine haematoxylin and eosin staining.
“What we’re recommending is that the protein section of MyPlate, the government’s food guide on how to eat a healthy diet, start with beans, peas and lentils. We advised that meat, including ...
Taking vitamins C and A can provide a boost to collagen production in the body. To maintain healthy skin, individuals can nurture and protect the collagen present in their bodies by consuming nutritious foods rich in the necessary vitamins, minerals, and amino acids. This promotes collagen production and reduces cellular damage within the body. [5]
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