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4-AcO-DMT is a prodrug of psilocin (4-HO-DMT). [2] As a prodrug of psilocin, 4-AcO-DMT acts as a non-selective agonist of serotonin receptors , including of the serotonin 5-HT 2A receptor . [ 1 ] The psychedelic effects of 4-AcO-DMT are mediated specifically by activation of the serotonin 5-HT 2A receptor.
Psilacetin (O-acetylpsilocin; 4-AcO-DMT) – non-selective serotonin receptor agonist and psychedelic hallucinogen – substance-related disorders – Psilera [180] Psilocin (PLZ-1015) – non-selective serotonin receptor agonist and psychedelic hallucinogen – pervasive child development disorders – Pilz Bioscience [181]
4-acetoxy-MET (4-acetoxy-N-methyl-N-ethyl tryptamine), also known as 4-AcO-MET or metacetin, is a hallucinogenic tryptamine. It is the acetate ester of 4-HO-MET, and a homologue of 4-AcO-DMT. It is a novel compound with very little history of human use. [2] It is sometimes sold as a research chemical by online retailers.
In addition to psilocybin, psilocin and 4-AcO-DMT, Garrett said, mushroom products can contain other psychoactive tryptamines, as well as an array of other compounds.
Psilocin, also known as 4-hydroxy-N,N-dimethyltryptamine (4-OH-DMT), is a substituted tryptamine alkaloid and a serotonergic psychedelic. It is present in most psychedelic mushrooms [ 7 ] together with its phosphorylated counterpart psilocybin .
4-AcO-DMT (O-acetylpsilocin) is an acetylated analog of psilocin. Additionally, replacement of a methyl group at the dimethylated nitrogen with an isopropyl or ethyl group yields 4-HO-MIPT and 4-HO-MET, respectively. [51]
In rodents, 4-HO-TMT showed no head-twitch response (a behavioral proxy of psychedelic effects), hypolocomotion, or hypothermia, in contrast to psilocin and norpsilocin, but similarly to aeruginascin. [3] A synthetic prodrug of 4-HO-TMT, 4-AcO-TMT, has been developed. [1] [5] It is analogous to psilacetin (4-AcO-DMT), a prodrug of psilocin. [1] [5]
The following is a list of psychedelic drugs of various chemical classes, including both naturally occurring and synthetic compounds. Serotonergic psychedelics are usually considered the "classical" psychedelics [dubious – discuss], whereas the other classes are often seen as having only secondary psychedelic properties; nonetheless all of the compounds listed here are considered ...