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Spermine synthase is an enzyme involved in polyamine biosynthesis. It is present in all eukaryotes and plays a role in a variety of biological functions in plants [ 3 ] Its structure consists of two identical monomers of 41 kDa with three domains each, creating a homodimer formed via dimerization .
Spermine biosynthesis in animals starts with decarboxylation of ornithine by the enzyme Ornithine decarboxylase in the presence of PLP. This decarboxylation gives putrescine . Thereafter the enzyme spermidine synthase effects two N-alkylation by decarboxy- S -adenosyl methionine .
671878 Ensembl ENSG00000102172 n/a UniProt P52788 P97355 RefSeq (mRNA) NM_001258423 NM_004595 XM_001473434 RefSeq (protein) NP_001245352 NP_004586 NP_033240 NP_001346114 Location (UCSC) Chr X: 21.94 – 21.99 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Spermine synthase is an enzyme that in humans is encoded by the SMS gene. The protein encoded by this gene belongs to the ...
Spermidine synthase is an enzyme (EC 2.5.1.16) that catalyzes the transfer of the propylamine group from S-adenosylmethioninamine to putrescine in the biosynthesis of spermidine. The systematic name is S-adenosyl 3-(methylthio)propylamine:putrescine 3-aminopropyltransferase and it belongs to the group of aminopropyl transferases.
Spermine synthase in turn helps the body produce spermine, a polyamine critical to cell processes such as cell division, tissue repair, and apoptosis. [5] The resulting shortage of spermine in cells causes problems with development and brain function, though the exact mechanism is not understood. The syndrome has also been referred to as Snyder ...
Spermidine synthase (SPDS) catalyzes its formation from putrescine. It is a precursor to other polyamines, such as spermine and its structural isomer thermospermine. Spermidine synchronizes an array of biological processes, (such as Ca 2+, Na +, K +-ATPase) thus maintaining membrane potential and controlling intracellular pH and volume.
Thermospermine synthase (EC 2.5.1.79, TSPMS, ACL5 (ACAULIS5), SAC51) is an enzyme with systematic name S-adenosylmethioninamine:spermidine 3-aminopropyltransferase (thermospermine synthesizing). [ 1 ] [ 2 ] [ 3 ] This enzyme catalyses the following chemical reaction
S-Adenosylmethioninamine is a substrate that is required for the biosynthesis of polyamines including spermidine, spermine, and thermospermine. [1] It is produced by decarboxylation of S-adenosyl methionine.