Search results
Results from the WOW.Com Content Network
Without cyclin, CDK is less active than in the cyclin-CDK heterodimer complex. [ 5 ] [ 6 ] CDKs phosphorylate proteins on serine (S) or threonine (T) residues. The specificity of CDKs for their substrates is defined by the S/T-P-X-K/R sequence, where S/T is the phosphorylation site, P is proline, X is any amino acid, and the sequence ends with ...
In CDK-cyclin complexes, this activation region is composed of a conserved αL-12 Helix and contains a key phosphorylatable residue (usually Threonine for CDK-cyclin partners, but also includes Serine and Tyrosine) that mediates the enzymatic activity of the CDK. It is at this essential residue (T160 in CDK2 complexes, T177 in CDK6 complexes ...
The Cdc7/Dbf4 kinase complex, along with another serine-threonine kinase, cyclin-dependent kinase (Cdk), phosphorylates the pre-RC which activates it at the G1/S transition. The Dbf4 tethers itself to part of the pre-RC, the origin recognition complex (ORC). Since Cdc7 is attached to the Dbf4 protein the entire complex is held in place during ...
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28 , and Schizosaccharomyces pombe cdc2 , and are known to be important regulators of cell cycle progression .
The CDK4 gene is located on chromosome 12 in humans. [7] The gene is composed of 4,583 base pairs which together code for the 303 amino acid protein with a molecular mass of 33,730 Da. [7] [8] All CDK proteins, including CDK4, have two lobes: the smaller N-terminal lobe (which contains an inhibitory G-loop), and the C terminal lobe (which contains an activation domain and a T-loop).
1017 12566 Ensembl ENSG00000123374 ENSMUSG00000025358 UniProt P24941 P97377 RefSeq (mRNA) NM_001290230 NM_001798 NM_052827 NM_016756 NM_183417 RefSeq (protein) NP_001277159 NP_001789 NP_439892 NP_058036 NP_904326 Location (UCSC) Chr 12: 55.97 – 55.97 Mb Chr 10: 128.53 – 128.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase 2, also known as cell division ...
CDK shareholders will receive $54.87 per share in cash, implying a 30% premium to the February 18 closing price, the last full trading day before market speculation regarding a potential sale.
12568 Ensembl ENSG00000164885 ENSMUSG00000028969 UniProt Q00535 P49615 RefSeq (mRNA) NM_001164410 NM_004935 NM_007668 RefSeq (protein) NP_001157882 NP_004926 NP_031694 Location (UCSC) Chr 7: 151.05 – 151.06 Mb Chr 5: 24.62 – 24.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 ...