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Alpha-keratin, or α-keratin, is a type of keratin found in mammalian vertebrates. This protein is the primary component in hairs , horns , claws , nails and the epidermis layer of the skin . α-keratin is a fibrous structural protein , meaning it is made up of amino acids that form a repeating secondary structure.
Keratin (/ ˈ k ɛr ə t ɪ n / [1] [2]) is one of a family of structural fibrous proteins also known as scleroproteins. It is the key structural material making up scales , hair , nails , feathers , horns , claws , hooves , and the outer layer of skin in vertebrates.
The first sequences of keratins revealed that keratins could be grouped into two categories based on their sequence homologies. [1] [2] These two groups of keratins were named as type I and type II keratins. [2]
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The naming convention for these keratins follows that for protein structures: alpha keratin is helical and beta keratin is sheet-like. Alpha keratin is found in mammalian hair, skin, nails, horn and quills, while beta keratin can be found in avian and reptilian species in scales, feathers, and beaks. The two different structures of keratin have ...
Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene. [5] [6] [7]The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails.
3881 16671 Ensembl ENSG00000094796 ENSG00000262993 ENSMUSG00000057723 UniProt Q15323 Q61897 RefSeq (mRNA) NM_002277 NM_013570 RefSeq (protein) NP_002268 NP_038598 Location (UCSC) Chr 17: 41.39 – 41.4 Mb Chr 11: 99.91 – 99.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Keratin, type I cuticular Ha1 is a protein that in humans is encoded by the KRT31 gene. Function The protein ...
KRT71 is a keratin gene. Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. [ 5 ] [ 6 ] This gene encodes a protein that is expressed in the inner root sheath of hair follicles . [ 6 ]