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For example, in mouse models, 24 hours after exposure to L-asparaginase, tumors resistant to the depletion responded with 5- to 19-fold increases in asparagine synthetase expression. [10] These resistant tumors also inherently express higher levels of asparagine synthetase activity, even without the application of L-asparaginase to drive ...
Asparaginase is an enzyme that is used as a medication and in food manufacturing. [6] [7] As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). [6] It is given by injection into a vein, or muscle. [6] A pegylated version is also available. [8] In food manufacturing it is used to ...
There can be many years between promising laboratory work and the availability of an effective anti-cancer drug: Monroe Eliot Wall discovered anti-cancer properties in Camptotheca in 1958, but it was not until 1996 – after further research and rounds of clinical trials – that topotecan, a synthetic derivative of a chemical in the plant, was ...
66514 Ensembl ENSG00000162174 ENSMUSG00000024654 UniProt Q7L266 Q8C0M9 RefSeq (mRNA) NM_001083926 NM_025080 NM_025610 RefSeq (protein) NP_001077395 NP_079356 NP_079886 Location (UCSC) Chr 11: 62.34 – 62.39 Mb Chr 19: 9.09 – 9.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse L-asparaginase is an enzyme that in humans is encoded by the ASRGL1 gene. Function The ASRGL1 protein ...
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Calaspargase pegol is an engineered protein consisting of the E. coli-derived enzyme L-asparaginase II conjugated with succinimidyl carbonate monomethoxypolyethylene glycol . [6] The L-asparaginase portion hydrolyzes L-asparagine to L-aspartic acid depriving the tumor cell of the L-asparagine it needs for survival. [ 6 ]
Cancer Research UK note that superfoods are often promoted as having an ability to prevent or cure diseases, including cancer; they caution, "a healthy, balanced and varied diet can help to reduce the risk of cancer but it is unlikely that any single food will make a major difference on its own." [32]
Vincristine, also known as leurocristine and marketed under the brand name Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. [5] This includes acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small cell lung cancer among others. [5] It is given intravenously. [5]