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  2. General transcription factor - Wikipedia

    en.wikipedia.org/wiki/General_transcription_factor

    A transcription factor is a protein that binds to specific DNA sequences (enhancer or promoter), either alone or with other proteins in a complex, to control the rate of transcription of genetic information from DNA to messenger RNA by promoting (serving as an activator) or blocking (serving as a repressor) the recruitment of RNA polymerase.

  3. Kruppel-like factors - Wikipedia

    en.wikipedia.org/wiki/Kruppel-like_factors

    KLFs are divided into three subgroups; Group 1 (KLF 3,8, and 12) are repressors via interaction with the C-terminal Binding Protein 1 and 2 (CtBP1 and CtBP2). Group 2 (KLFs 1,2,4,5,6, and 7) are transcription activators. Group 3 (KLFs 9,10,11,13,12, and 16) have repressor activity via interaction with the common transcriptional co-repressor ...

  4. Transcription coregulator - Wikipedia

    en.wikipedia.org/wiki/Transcription_coregulator

    Transcription factor glossary; gene expression – the process by which information from a gene is used in the synthesis of a functional gene product such as a protein ...

  5. Activator (genetics) - Wikipedia

    en.wikipedia.org/wiki/Activator_(genetics)

    A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.

  6. Silencer (genetics) - Wikipedia

    en.wikipedia.org/wiki/Silencer_(genetics)

    The Polycomb Repressive Complex 1 (PRC 1) is directly involved in the process of hematopoiesis, and functions together with, for example, the PcG gene “Bmi1”. Studies in mice indicate that organisms with mutated “Bmi1” demonstrate deficient mitochondrial functioning, and also hindered the ability of hematopoietic cells to self-renew.

  7. SOS response - Wikipedia

    en.wikipedia.org/wiki/SOS_response

    The activated form of RecA interacts with the LexA repressor to facilitate the LexA repressor's self-cleavage from the operator. [7] [8] Once the pool of LexA decreases, repression of the SOS genes goes down according to the level of LexA affinity for the SOS boxes. [7] Operators that bind LexA weakly are the first to be fully expressed.

  8. Transcriptional regulation - Wikipedia

    en.wikipedia.org/wiki/Transcriptional_regulation

    If the repressor has a higher affinity for its motif than the activator, transcription would be effectively blocked in the presence of the repressor. Tight regulatory control is achieved by the highly dynamic nature of transcription factors.

  9. Coactivator (genetics) - Wikipedia

    en.wikipedia.org/wiki/Coactivator_(genetics)

    A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes. [1] The activator contains a DNA binding domain that binds either to a DNA promoter site or a specific DNA regulatory sequence called an enhancer .

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