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2. E2F - Wikipedia

   en.wikipedia.org/wiki/E2F

   E2F activator levels are cyclic, with maximal expression during G1/S. In contrast, E2F repressors stay constant, especially since they are often expressed in quiescent cells. Specifically, E2F5 is only expressed in terminally differentiated cells in mice. [2] The balance between repressor and activator E2F regulate cell cycle progression.

3. Kruppel-like factors - Wikipedia

   en.wikipedia.org/wiki/Kruppel-like_factors

   KLFs are divided into three subgroups; Group 1 (KLF 3,8, and 12) are repressors via interaction with the C-terminal Binding Protein 1 and 2 (CtBP1 and CtBP2). Group 2 (KLFs 1,2,4,5,6, and 7) are transcription activators. Group 3 (KLFs 9,10,11,13,12, and 16) have repressor activity via interaction with the common transcriptional co-repressor ...

4. Activator (genetics) - Wikipedia

   en.wikipedia.org/wiki/Activator_(genetics)

   A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.

5. RE1-silencing transcription factor - Wikipedia

   en.wikipedia.org/wiki/RE1-silencing...

   This gene encodes a transcriptional repressor which represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element (NRSE, also known as RE1).

6. Silencer (genetics) - Wikipedia

   en.wikipedia.org/wiki/Silencer_(genetics)

   1: RNA Polymerase, 2: Repressor (LacI), 3: Promoter, 4: Operator, 5: Lactose, 6: lacZ, 7: lacY, 8: lacA. Top: lac operon is initially repressed because lactose is not present to inhibit the repressor. Bottom: Repressor LacI is inhibited because it binds to lactose and transcription of the lac operon is initiated for the breakdown of lactose.

7. Transcription coregulator - Wikipedia

   en.wikipedia.org/wiki/Transcription_coregulator

   Transcription factor glossary; gene expression – the process by which information from a gene is used in the synthesis of a functional gene product such as a protein ...

8. Corepressor - Wikipedia

   en.wikipedia.org/wiki/Corepressor

   A corepressor downregulates (or represses) the expression of genes by binding to and activating a repressor transcription factor. The repressor in turn binds to a gene's operator sequence (segment of DNA to which a transcription factor binds to regulate gene expression), thereby blocking transcription of that gene.

9. Coactivator (genetics) - Wikipedia

   en.wikipedia.org/wiki/Coactivator_(genetics)

   A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes. [1] The activator contains a DNA binding domain that binds either to a DNA promoter site or a specific DNA regulatory sequence called an enhancer .