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Today, the mortality rate with treatment is in the range 5% to 15%, after the introduction of corticosteroids as primary treatment. [3] Nevertheless, in 1998, pemphigus vulgaris was the fourth most common cause of death due to a skin disorder. It is thus still deemed "potentially fatal". Pemphigus vulgaris on face
Bullous pemphigoid, pemphigus vulgaris, friction blisters, insect bites [5] Treatment: Wound care, pain control, controlling infections, nutritional support [2] Prognosis: Death usually occurs during early adulthood: Frequency: around 1 in 500,000 [5]
Paraneoplastic pemphigus (PNP) is an autoimmune disorder stemming from an underlying tumor.It is hypothesized that antigens associated with the tumor trigger an immune response resulting in blistering of the skin and mucous membranes.
Pemphigus is further divided in two major subtypes: pemphigus vulgaris (PV) and pemphigus foliaceus (PF). However, several other disorders such as IgA pemphigus, IgE pemphigus, pemphigus herpetiformis, drug-induced pemphigus, Senear Usher syndrome, and endemic pemphigus foliaceus exist, and are recognized by a dermatologist from the appearance ...
SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).
Mucosal pemphigus vulgaris: IgG: Desmoglein 3: 130 Mucocutaneous pemphigus vulgaris: IgG: Desmoglein 3 Desmoglein 1: 130 160 Pemphigus foliaceus: IgG: Desmoglein 1: 160 Paraneoplastic pemphigus: IgG: Desmoglein 3 Desmoglein 1 BPAG1 [nb 1] Plectin Desmoplakin I [nb 2] Desmoplakin II Envoplakin Periplakin Alpha-2-macroglobulin-like-1: 130 160 230 ...
In more severe treatment it is treated similarly to pemphigus vulgaris. Pemphigus foliaceus is an autoimmune blistering disease of the skin. [ 1 ] Pemphigus foliaceus causes a characteristic inflammatory attack at the subcorneal layer of epidermis , which results in skin lesions that are scaly or crusted erosions with an erythematous (red) base ...
Very rarely seen in children, bullous and non-bullous pemphigoid most commonly occurs in people 70 years of age and older. [2] Its estimated frequency is seven to 14 cases per million per year, but has been reported to be as high as 472 cases per million per year in Scottish men older than 85. [ 2 ]