Search results
Results from the WOW.Com Content Network
In this pedigree chart, G is the progeny of C and F, and C is the biological uncle of F. To find the coefficient of inbreeding of G, first locate a loop that leads from G to the common ancestor through one parent and back down to the other parent without going through the same individual twice. There are only two such loops in this chart, as ...
The coefficient of relationship is a measure of the degree of consanguinity (or biological relationship) between two individuals. The term coefficient of relationship was defined by Sewall Wright in 1922, and was derived from his definition of the coefficient of inbreeding of 1921. The measure is most commonly used in genetics and genealogy.
F IT is the inbreeding coefficient of an individual (I) relative to the total (T) population, as above; F IS is the inbreeding coefficient of an individual (I) relative to the subpopulation (S), using the above for subpopulations and averaging them; and F ST is the effect of subpopulations (S) compared to the total population (T), and is ...
With continuous inbreeding, genetic variation is lost and homozygosity is increased, enabling the expression of recessive deleterious alleles in homozygotes. The coefficient of inbreeding, or the degree of inbreeding in an individual, is an estimate of the percent of homozygous alleles in the overall genome. [69]
Malecot's coancestry coefficient, , refers to an indirect measure of genetic similarity of two individuals which was initially devised by the French mathematician Gustave Malécot. f {\displaystyle f} is defined as the probability that any two alleles , sampled at random (one from each individual), are identical copies of an ancestral allele.
In clinical genetics, consanguinity is defined as a union between two individuals who are related as second cousins or closer, with the inbreeding coefficient (F) equal or higher than 0.0156, where (F) represents the proportion of genetic loci at which the child of a consanguineous couple might inherit identical gene copies from both parents. [25]
The fixation index (F ST) is a measure of population differentiation due to genetic structure. It is frequently estimated from genetic polymorphism data, such as single-nucleotide polymorphisms (SNP) or microsatellites. Developed as a special case of Wright's F-statistics, it is one of the most commonly used statistics in population genetics ...
Population structure (also called genetic structure and population stratification) is the presence of a systematic difference in allele frequencies between subpopulations. In a randomly mating (or panmictic ) population, allele frequencies are expected to be roughly similar between groups.