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The discovery of disease-causing pathogens is an important activity in the field of medical science. Many viruses, bacteria, protozoa, fungi, helminths (parasitic worms), and prions are identified as a confirmed or potential pathogen.
Mycobacterium is a genus of over 190 species in the phylum Actinomycetota, assigned its own family, Mycobacteriaceae.This genus includes pathogens known to cause serious diseases in mammals, including tuberculosis (M. tuberculosis) and leprosy in humans.
The other disease called flacherie caused silkworms to become dark brown. Pébrine was thought to be a form of flacherie since it caused brown dots on the silkworms. [49] [56] But, Pasteur discovered Pébrine and flacherie were separate diseases. Pasteur claimed bacteria within the silkworms' intestinal track caused flacherie.
The fungal cell wall is made of a chitin-glucan complex; while glucans are also found in plants and chitin in the exoskeleton of arthropods, [36] fungi are the only organisms that combine these two structural molecules in their cell wall. Unlike those of plants and oomycetes, fungal cell walls do not contain cellulose. [37] [38]
The cell wall of bacteria is also distinct from that of achaea, which do not contain peptidoglycan. The cell wall is essential to the survival of many bacteria, and the antibiotic penicillin (produced by a fungus called Penicillium) is able to kill bacteria by inhibiting a step in the synthesis of peptidoglycan. [76]
The mycolic acids in the bacteria's cell walls afford resistance to many antibiotics and are a major virulence factor. [49] Multidrug therapy (MDT) was recommended by WHO Expert Committee in 1984, and became the standard leprosy treatment. MDT has been supplied by WHO for free since 1995 to endemic countries.
However, the mycolic acid in the cell wall of M. tuberculosis does not absorb the stain. Instead, acid-fast stains such as Ziehl–Neelsen stain, or fluorescent stains such as auramine are used. [4] Cells are curved rod-shaped and are often seen wrapped together, due to the presence of fatty acids in the cell wall that stick together. [11]
Carlos Justiniano Ribeiro Chagas, or Carlos Chagas (Portuguese: [ˈkaʁluz ʒustʃĩniˈɐ̃nu ʁiˈbejɾu ˈʃaɡɐs]; July 9, 1879 – November 8, 1934), was a Brazilian sanitary physician, scientist, and microbiologist who worked as a clinician and researcher.