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Steroidogenesis.Trilostane inhibits 3β-HSD. Trilostane is a steroidogenesis inhibitor. [1] It is specifically an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD). [1] [15] As a result of this action, trilostane blocks the conversion of Δ 5-3β-hydroxysteroids, including pregnenolone, 17α-hydroxypregnenolone, dehydroepiandrosterone (DHEA), and androstenediol, into Δ 4-3-ketosteroids ...
[10] [11] It is also used on its own to treat Cushing's Syndrome or for use as a low-dose emergency contraceptive. [12] [13] The most common adverse effects include abdominal pain, feeling tired, and vaginal bleeding. [8] Serious side effects may include heavy vaginal bleeding, bacterial infection, and, if pregnant, birth defects. [8]
Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
The most common cause of Cushing syndrome is long-term, high-dose use of glucocorticoids, medications used to treat other medical conditions like asthma, rheumatoid arthritis, and lupus, the NIDDK ...
Physicians usually recommend medications to patients whose adrenalism is not caused by cancer, since chemotherapy has been proven to be ineffective. [18] Common use of medications include drugs that suppress cortisol production in the adrenal gland by inhibiting 11-beta hydroxylase. Ketoconazole and metyrapone fall under this drug category. [19]
Osilodrostat's safety and effectiveness for treating Cushing's disease among adults was evaluated in a study of 137 adult subjects (about three-quarters women) with a mean age of 41 years. [3] The majority of subjects either had undergone pituitary surgery that did not cure Cushing's disease or were not surgical candidates. [ 3 ]
EAU CLAIRE — Six months ago, health care in the Chippewa Valley faced seismic changes. ... Eau Claire’s Mayo Clinic would be the only locally available critical care unit, and would remove the ...
Cushing syndrome, which is brought on by getting steroid injections in high doses, is characterized by a round, red and full face, as well as weight gain, thin skin and other symptoms.
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